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Isnin, 6 Jun 2011

Anti-Depression (SSRI)

anti-depression
by:
Dr. Hamidah
 
terdapat pelbagai jenis anti-depression
yang disentuh n dikongsi oleh Dr. Hamidah masa Jurnal Club hanya 1 jek:
Selective Serotonin Reuptake Inhibitors (SSRI)

contoh2 ubat nya ialah:
  • Sertraline --> 26 jam
  • Fluvoxamine (Luvox) --> 15 jam
  • Fluoxetine (Prozacs) --> 4-6 hari
  • Escitalopram --> 27-32 jam
Pharmacodynamics: meningkatkan kadar serotonin dalam synaps otak.

Indikasi:
  1. Depression
  2. Anxiety Disorder
  3. Eating Disorder
  4. Pre-menstrual Dysphoric Disorder
  5. Off label- premature ejaculation
side-effects:
  1. lasts for 4 weeks - as body adapts
  2. Sexual dysfunction
  3. Insomnia & sedation
  4. Weight gain
  5. Headache & dizziness
  6. Gastro-intestinal tract effects
  7. Serotonin Syndrome (rare) - usually happens in overdose cases.

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